Ligand-gated ion channels: mechanisms underlying ion selectivity
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چکیده
منابع مشابه
Allosteric coupling in ligand-gated ion channels
What does " allosteric " mean? In the context of receptors, the word allosteric is now widely used. It is, perhaps, not helpful for clarity of thought that different authors often use it to mean somewhat different things (Colquhoun, 1998). At one extreme, the term " allosteric antagonist " can often be translated as " we have got an antagonist and we are not sure what it does, but it appears no...
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Behavioral output of neural networks depends on a delicate balance between excitatory and inhibitory synaptic connections. However, it is not known whether network formation and stability is constrained by the sign of synaptic connections between neurons within the network. Here we show that switching the sign of a synapse within a neural circuit can reverse the behavioral output. The inhibitor...
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Ivermectin acts as a positive allosteric regulator of several ligand-gated channels including the glutamate-gated chloride channel (GluCl), gamma aminobutyric acid type-A receptor, glycine receptor, neuronal alpha7-nicotinic receptor and purinergic P2X4 receptor. In most of the ivermectin-sensitive channels, the effects of ivermectin include the potentiation of agonist-induced currents at low c...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2004
ISSN: 0079-6107
DOI: 10.1016/j.pbiomolbio.2003.09.002